Branched aminoglycosides: biochemical studies and antibacterial activity of neomycin B derivatives.

نویسندگان

  • Mariana Hainrichson
  • Varvara Pokrovskaya
  • Dalia Shallom-Shezifi
  • Micha Fridman
  • Valery Belakhov
  • Dina Shachar
  • Sima Yaron
  • Timor Baasov
چکیده

The C5''-OH group in neomycin B was glycosylated with a variety of mono- and di-saccharides to probe the effect of introduction of additional binding elements on antibacterial activity and interaction with the aminoglycosides modifying enzyme APH(3')-IIIa. The designed structures show antibacterial activity superior to that of neomycin B against pathogenic and resistant strains, while in parallel they demonstrate poor substrate activity with APH(3')-IIIa.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry

دوره 13 20  شماره 

صفحات  -

تاریخ انتشار 2005